Protein, Nucleotide Sequence Search

Finding identical, similar, homologous bio-sequences for you!

Biosequence search, encompassing protein sequence search and nucleotide sequence search, is a crucial tool in biotechnology and the pharmaceutical industry for identifying prior art that discloses protein, peptide, DNA, and RNA sequences identical or similar to a query sequence. This type of search is fundamental for ensuring that a given biological sequence is novel, supporting the development of new inventions across pharmaceutical, agricultural, and biotech industries.

The significance of biosequence search is rooted in historical achievements, such as the characterization of insulin protein sequences by Fred Sanger in 1951, a pioneering effort in the sequencing of long-strand molecules like DNA. This milestone underscored the importance of understanding biological sequences in advancing scientific knowledge and innovation.

Primary Uses of Biosequence Search:

1. Novelty Assessment: Determines whether a biosequence is unique, aiding in the patentability analysis for inventions.

2. Innovation Development: Facilitates the creation of new products and technologies in life sciences, especially within pharmaceutical, agricultural, and biotech sectors.

Types of Sequence Alignment:

1. Pair-wise Sequence Alignment: Compares two sequences to identify regions of similarity that may indicate functional, structural, or evolutionary relationships. Tools for pair-wise alignment include BLAST and dot plots.

2. Multiple Sequence Alignment: Analyzes more than two sequences to identify alignments that reveal sequence homology, evolutionary relationships, or functional similarities. Key tools for multiple alignments include ClustalW, PROBCONS, MUSCLE, MAFFT, and T-Coffee.